منابع مشابه
P20: The Role of Protein Kinases in Memory
When an experience is encrypted into a long-lasting memory, it is believed that specific sets of neurons in the brain of the animal undergo changes including the strengthening of preexisting synapses and the growth and maintenance of new synaptic connections. These activity-dependent synaptic changes appear to require the coordination of a variety of cellular processes in spatially separated ce...
متن کاملAtypical Protein Kinases (aPKs)
Atypical protein kinases lack sequence similarity to the ePK domain HMM profile, but have been shown experimentally to have protein kinase activity, or are clear homologs of aPKs with demonstrated protein kinase activity. All aPK families are small, several having just one member in vertebrates, and none in invertebrates. Other aPK families may remain to be discovered by biochemical methods, bu...
متن کاملDYRK protein kinases
Soppa and Becker introduce the DYRK family of dual specificity protein kinases and their diverse functions and associations with genetic diseases.
متن کاملProtein kinases and addiction.
Although drugs of abuse have different chemical structures and interact with different protein targets, all appear to usurp common neuronal systems that regulate reward and motivation. Addiction is a complex disease that is thought to involve drug-induced changes in synaptic plasticity due to alterations in cell signaling, gene transcription, and protein synthesis. Recent evidence suggests that...
متن کاملCUL3 and protein kinases
Posttranslational mechanisms drive fidelity of cellular processes. Phosphorylation and ubiquitination of substrates represent very common, covalent, posttranslational modifications and are often co-regulated. Phosphorylation may play a critical role both by directly regulating E3-ubiquitin ligases and/or by ensuring specificity of the ubiquitination substrate. Importantly, many kinases are not ...
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ژورنال
عنوان ژورنال: IUBMB Life
سال: 2019
ISSN: 1521-6543,1521-6551
DOI: 10.1002/iub.2065